It seems unlikely since it flies in the face of dozens of other studies see example from HIUK post. Meanwhile the sugar in the high fat diet is linked to weight gain and insulin resistance. The mouse model of diet-induced obesity has become one of the most important tools for understanding the interplay of high-fat Western diets and the development of obesity.
The problem is that the trials ignore other elements in each diet that have direct health effects. Generally, male mice are more affected by diabetes than are female mice and thus are used more often in diet-induced obesity studies Cancer, for instance, is easy to cure in rats get high fat diet and mice but, as researchers are well aware, the results usually fail to translate to humans.
But this is not a scientific paper. The phenotypic variations between these two inbred strains might be due to an altered hypothalamic gene expression 26leptin sensitivity 27sympathetic stimulation 28or epigenetic programming Some animals show profound increases in their body fat content while some are resistant to weight gain with high-fat diet 5.
No significant associations could be detected. Obesity is a complex, chronic disease, involving decades of pathophysiological changes and adaptation.
Not as far as I can tell. Although an increase in body weight can be noticed after 2 weeks, the increase is gradual and becomes apparent after 4 weeks. However, there are no reliable predictors for diabetes development or onset and the reported development of overt diabetes is controversial.
To circumvent some of these issues, several surrogate models are available, including murine genetic loss-of-function mutations, transgenic gain-of-function mutations, polygenic models, and different environmental exposure models. Mitochondrial citrate synthase and cytochrome oxidase activity decreased slightly with the high-fat diet, but heat treatment restored these activities.
Abstract Obesity is reaching pandemic proportions in Western society. Although these rules apply in general, it is important to remember that diet outcomes vary in different laboratories due to animal strain and diet variations. Why high fat diet studies on rats and mice are not to be trusted By Jerome Burne Over the past year I have been wondering whether there is something deeply flawed about research into the effects of high fat diets on rats and mice, done presumably to clarify the effects on humans.
These include weight loss with no cut in calories, increased energy, improved glucose tolerance and reduced insulin. NaCl 0. The UC Davis article is referring to a paper published in Cell Metabolism the previous year, which goes on to explain that rodent chow also contains lots of soy which has an oestrogen-like effect on how much food and water the animals want, how active they are and how much fat they store.
He is an award-winning journalist who has been specialising in medicine and health for the last 10 years and now works mainly for the Daily Mail. At that time, hyperinsulinemic-euglycemic clamp experiments will demonstrate whole-body insulin resistance.
Rats have some advantages over mice when performing metabolic studies due to their larger size e. This is not research, it is a rigged game.
Shown are exemplary studies highlighting the range of changes observed. What is going on? The high-fat diet's effects on blood glucose are more discrepant and depend on the type of dietary regimen.
Its intention is to point up a serious and avoidable source of confusion in an area already rife with confusion and misinformation.
It has resulted in increasing health care burden and decreasing life expectancy. The weekly weight gain is shown for the first 11 diet weeks. The forty-year-old standard advice warning us off saturated fat is looking increasingly dated, even though experts in some quarters — looking at you Diabetes UK— still cling to it.
There was no attempt to suggest that the reaction of rodents might be different to that of humans — a basic caveat with any animal research. In the past 20—30 years, there have been many studies characterizing the responses of animals exposed to high-fat diets 4.
Heat treatment and overexpression of heat shock protein 72 HSP72 have been shown to protect against high-fat diet-induced insulin resistance, but little is known about the underlying mechanism or the target tissue of HSP action. Recent studies have shown that S6K1-deficient mice and Akt1 knockout mice exhibit are prevented from diet-induced obesity through model of murine high-fat diet induced obesity described below Low carbohydrate diet helps humans lose weight The confusion this fake research is intentionally?
In fact it seems the rodent work is highly misleading. So are the results telling us that the increasingly popular low carb high fat approach is wrong? This pushed up their weight and their glucose levels; grapefruit juice reduced both. Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet.
The elevation of fasting glucose is usually accompanied by increases in fasting insulin levels. With special thanks to Peter Dobromylskyj a vet with physiology degree, who runs a very sophisticated academic blog on diet and health at http:Rats need: Fresh/healthy/balanced diets meeting their nutritional needs; easily achieved by feeding balanced commercial pelleted diets especially for rats.
Occasional variety. Consider supplementing diets with small amounts of fruit/vegetables/cooked egg/grains/seeds, given as part of their daily ration, not in addition or it could cause obesity/health problems.
Rats are omnivores eating both plant and animal. Wenche Jørgensen, Kasper A. Rud, Ole H. Mortensen, Lis Frandsen, Niels Grunnet and Bjørn Quistorff, Your mitochondria are what you eat: a high‐fat or a high‐sucrose diet eliminates metabolic flexibility in isolated mitochondria from rat skeletal muscle, Physiological Reports, 5, 6, ().Cited by: Not only are the so called ‘high fat diets’ they are fed nothing like the low carbohydrate diets any informed human would follow, but the animals have been selectively bred to ensure they become fat and diabetic on a high fat diet.
This is not research, it is a rigged game. Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet.
Gupte AA(1), Bomhoff GL, Swerdlow RH, Geiger PC. Author information: (1)Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, elbfrollein.com by: Nevertheless, the full manifested picture of obesity develops after 16 weeks of high-fat diet with adipocyte hyperplasia, fat deposition in mesentery, increased fat mass, diabetes, and hypertension.
Akt and mTOR pathyway integrates several important signals that regulate cell growth and elbfrollein.com by: